Ozempic (Semaglutide) for Diabetes

Overview
Ozempic is a prescription drug approved by the U.S. Food and Drug Administration (FDA) to improve glycemic control in adults with type 2 diabetes. It is prescribed as an add-on therapy to diet and exercise. Additionally, Ozempic is FDA-approved to reduce the risk of major cardiovascular (heart) events in adults with type 2 diabetes and established cardiovascular disease. It is also approved to lower the risk of sustained estimated glomerular filtration rate (eGFR) decline, end-stage kidney disease, and cardiovascular death in adults with type 2 diabetes and chronic kidney disease. Ozempic is also known by its drug name, semaglutide.

Ozempic is a type of medication called a GLP-1 receptor agonist. It works by mimicking natural hormones that help the body release insulin, lower sugar production in the liver, and slow digestion to keep blood glucose (sugar) levels stable.

How do I take it?
Ozempic is available as a prefilled, single-use pen. Prescribing information states that Ozempic should be administered as a subcutaneous (under the skin) injection once a week at any time of day, with or without meals. The injection can be administered in the abdomen, thigh, or upper arm. Treatment typically starts at a lower dose and increases over time if necessary. It should be taken exactly as prescribed by a healthcare provider.

Side effects
Prescribing information lists common side effects of Ozempic including nausea, vomiting, diarrhea, abdominal pain, and constipation.

Rare but serious side effects may include pancreatitis (inflammation of the pancreas), acute kidney injury, severe gastrointestinal issues (such as vomiting or difficulty with digestion), complications in people with diabetic retinopathy (eye problems related to diabetes), hypersensitivity reactions (such as anaphylaxis), acute gallbladder disease (such as gallstones or gallbladder inflammation), and pulmonary aspiration (inhalation of stomach contents) during general anesthesia or deep sedation.

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Ozempic Semaglutide Injection — Novo Nordisk