Xigduo XR (Dapagliflozin/Metformin) for Diabetes

Overview
Xigduo is a prescription drug approved by the Food and Drug Administration (FDA) to help improve blood glucose control in adults with type 2 diabetes. Xigduo is considered an adjunct treatment to diet and exercise.

Xigduo is a combination drug composed of the drugs Dapagliflozin, the active ingredient in Farxiga, and Metformin. Dapagliflozin is a sodium-glucose transporter 2 (SGLT2). Dapagliflozin is believed to work by causing excess glucose to be eliminated in the urine. Metformin is a biguanide. Metformin is believed to work by decreasing the amount of glucose produced by the liver and making the muscle tissue more sensitive to insulin.

How do I take it?
Prescribing information states that Xigduo is generally taken once daily in the morning with breakfast.

Xigduo comes in tablet form.

Side effects
The FDA-approved label for Xigduo lists common side effects including urinary tract infections, yeast infections in women, cold symptoms, diarrhea, nausea, vomiting, and headache.

Rare but serious side effects listed for Xigduo include lactic acidosis (when the tissues and blood become too acidic) and systemic allergic reaction.

For answers to frequently asked questions about exposure to Metformin during pregnancy and breastfeeding, visit the experts at MothertoBaby.org.