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Lantus Vs The Other Long Lasting Insulins

A DiabetesTeam Member asked a question πŸ’­

I'm on Lantus-20 units at night, Trulicity .75, and Novolog sliding scale. My insurance will no longer pay for Lantus. The alternates are Basaglar, Levemir, and Tresiba. Which one is the best? I hear there is a trial going on for a weekly long lasting insulin. Any thoughts?

February 7, 2023
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A DiabetesTeam Member

If you are otherwise happy with the Lantus then Basaglar is "identical" - same insulin, same formula, same production

Lantus is made by Sanofi and Basaglar is made by Mylan - so simply two different companies both are "glargine" type insulin - a human insulin that is just (reproduced) lab grown

Levimir is from a different class - "detemer" made by Novo Nordisk - a gigantic insulin mfg - also a human insulin - works the same as above, just a different formula

The Tresiba is yet another (type) called "degludec", also made by Novo Nordisk - it's a lab enhanced insulin (they tried to build a better mouse trap) - and is described as ultra-long acting so should treat longer then any of the other options

If you want "no change", you are happy with what you were using, the Basaglar is identical

But if you want "an improved version" the Tresiba should, in theory, be the best choice.

Did you discuss the pros/cons of your (new) options with your Doc? They may have some additional insight, experience or preference and can better advise

February 7, 2023
A DiabetesTeam Member

I've been on Tresiba now almost a year, doing well for me.

February 7, 2023
A DiabetesTeam Member

When comparing Lantus (Insulin glargine) to other long-acting insulins, here are some key points based on the knowledge base:

Lantus (Insulin glargine)
- Type: Long-acting insulin
- Administration: Subcutaneous injection, once daily at the same time each day
- Forms: Liquid in vials or prefilled pens
- Common Side Show Full Answer

When comparing Lantus (Insulin glargine) to other long-acting insulins, here are some key points based on the knowledge base:

Lantus (Insulin glargine)
- Type: Long-acting insulin
- Administration: Subcutaneous injection, once daily at the same time each day
- Forms: Liquid in vials or prefilled pens
- Common Side Effects: Hypoglycemia, hypokalemia, weight gain, minor redness or irritation at injection sites
- Rare but Serious Side Effects: Systemic allergic reaction

Other Long-Acting Insulins
- Degludec (Tresiba)
- Type: Long-acting insulin
- Duration: Effective for about 36 hours or longer
- Detemir (Levemir)
- Type: Long-acting insulin
- Duration: Effective for up to 24 hours
- Glargine U-300 (Toujeo)
- Type: Ultra long-acting insulin
- Administration: Subcutaneous injection, once daily at the same time each day
- Forms: Prefilled pen
- Common Side Effects: Hypoglycemia, hypokalemia, weight gain, rash, minor redness or irritation at injection sites

Summary
- Lantus and Toujeo are both forms of insulin glargine but differ in concentration and duration.
- Tresiba offers a longer duration of action compared to Lantus.
- Levemir has a similar duration to Lantus but may require different dosing schedules.

Each insulin type has its own specific characteristics and side effects, and the choice of insulin should be tailored to individual needs and medical advice.

July 31

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