Glimepiride is the "newest" version in the class, considered the only 3rd Generation Sulfonylurea at the moment

They have worked some of the (danger) out of it - only see lows in about 3% of the users. It's upwards of 30% in some of the second generation stuff, so if that is an option then maybe worth a discussion with the Doc

I'm very familiar with Glyburide - same class, almost the same formula - it's the "Canadian" standard for SU's (sulfonylurea's)

As Henry notes - stuff works great - turns your pancreas into a Insulin "spewing machine", so does tend to cause lows until you really get a handle on "how much to eat for a given dose"

It's taken almost exactly like mealtime insulin a number of minutes before eating and it does it's thing - eat too many carbs you are still high, too few and you go low

In Canada it is recommended that you wear a CGM if you use SU's because an accidental overdose can kill you

That's why the stuff is cheap - it's generic, has been around about 80 years, works really well, just takes a lot of "user input" which is why the drug class is not typically prescribed unless cost is a factor or someone wants a last ditch try to stay off insulin

Personally, I would rather take an SU then some of the other drugs out there that haven't been on the market more than 5 or 10 years - we know everything that SU's "do and don't do" to you if you take them for decades - Ozempic is anybody's guess - it was only approved in 2017 so the most "senior user" has only been on it 7 years - will it still be "safe" to take after 10 years???

Just my take on it

Thats a sulfonurea, cost effective, but hypos are a frequent problem, so eat at regular, consistant times.

Thanks for the information really appreciate it this is what worries me the loss as I do a lot of running about with work ,I am only on sitaglipton one a day at moment thanks take care:)